Reichmann Lab

M. Radzinski, O. Yogev, T. Oppenheim, R. Fassler, W. Breuer, N. Shai, E. Brielle, R. Israeli, I. Arkin, E. Pick, T. Ravid, M. Schuldiner, D. Reichmann. A molecular switch for Cdc48 activity and localization during oxidative stress and aging, BioRxiv: 733709

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W. He, G. Yu, T. Li, L. Bai, Z. Xue, Y. Pang, D. Reichmann,  S. Hiller, L. He, M. Liu, S. Quan. Chaperone Spy protects outer membrane proteins from folding stress via dynamic complex formation,  2021, mBio, in press

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R. Fassler, L. Zualy, N. Lahrach, M. Ilbert, D. Reichmann, The central role of redox-regulated switch proteins in bacteria, 2021, Front. Mol. Bios, 8: 706039

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M. Radzinski, T. Oppenheim, N. Metanis, D. Reichmann. The Cys Sense: Thiol Redox Switches Mediate Life Cycles of Cellular Proteins, 2021, Biomolecules, 11(3), 469

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S. Aramin, R. Fassler, V. Chikne, M. Goldenberg, T. Arian, O. Rimon, L. Kolet, S. Michaeli, and D. Reichmann. TrypOX, a novel eukaryotic homologue of redox-regulated chaperone Hsp33 in Trypanosoma brucei, 2020, Frontiers in Microbiology,  11:1844

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M. Mahameed, S. Boukeileh, A. Sulieman, A. Obiedat, O. Darawshi, P. Dipta, A. Rimon, G. McLennan, R. Fassler, D. Reichmann, R. Karni, C. Preisinger, T. Wilhelm, M. Huber and B. Tirosh, Pharmacological induction of selective endoplasmic reticulum retention as a novel strategy for cancer therapy, 2020, Nature Communication, 11(1):1304

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HW. Reuter, T. Masuch, N. Ke, M. Lenon, M. RadzinskiS, V. Van Loi, G. Ren, P. Riggs, H. Antelmann, D. Reichmann, L. I. Leichert and M. Berkmen, Utilizing redox-sensitive GFP fusions to detect in vivo redox changes in a genetically engineered prokaryote, 2019, Redox Biology, 26:101280

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E. Kassa, E. Zlorkin-Rivkin, G. Friedman, R. Ramachandran, N. Melamed-Book, A. Weiss, M. Belenky, D. Reichmann, W. Breuer, L. Goldenring, J. Goldenring, B. Aroeti, Enteropathogenic Escherichia coli remodels host endosomes to promote endocytic turnover and breakdown of surface polarity, 2019, PloS Pathogens, 15(6):e1007851

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G. Masson, …D. Reichmann,….K. Rand, Recommendations for the practice, interpretation and reporting of hydrogen deterium exchanges mass spectrometry (HDX-MS) experiments, 2019, Nature Methods, 16(7):595-602

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C. Iacobucci, …. N. Edinger,… R. Mesika, … D. Reichmann, … A. Sinz, Cross-linking/Mass Spectrometry: A Community-Wide, Comparative Study Towards Establishing Best Practice Guidelines, 2019, Anal. Chemistry, 91(11):6953-6961

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G. Erdos, B. Meszaros, D.Reichmann and Z. Dosztanyi, Large-Scale Analysis of Redox-Sensitive Conditionally Disordered Protein Regions Reveals Their Widespread Nature and Key Roles in High-Level Eukaryotic Processes, 2019 , Proteomics, e1800070

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R. Mesika and D. Reichmann,When safeguarding goes wrong: Impact of oxidative stress on protein homeostasis in health and neurodegenerative disorders. Adv Protein Chem Struct Biol., 2019; 114:221-264

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Bramasole L, Sinha A, Gurevich S, Radzinski M, Klein Y., Panat N, Gefen E , Jimenez-Morales D, Johnson J , Krogan NJ, Reis N, Rinaldi T, Reichmann D, Glickman MH, and Pick E, Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 rubylation status, Redox Biology, 20:533-543. 

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E. Keinan, A. Abraham, R. Mintz, M. Cohen, D. Reichmann, D. Kaganovich, Y. Nahmias. High-Reynolds Microfluidic Sorting of Large Yeast Population Demonstrates Early Age-Dependent Changes in Protein Quality Control. 2018, Sci. rep, 8(1):13739 

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M. Radzinski and D. Reichmann, Variety is the spice of life: how to explore a redox-dependent heterogeneity in genomically identical cellular populations. 2018, Current genetics, 65(1):301-306

 

M. Radzinski, R. Fassler, O. Yogev, W. Breuer, N. Shai, J. Gutin, S. Ilyas, Y. Geffen, S. Tsytkin-Kirschenzweig, Y. Nahmias, T. Ravid, N. Friedman, M. Shueldiner and D. Reichmann. Temporal profiling of redox-dependent heterogeneity in single cells. 2018, eLife, 7:e37623.

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R. Fassler*, N.  Edinger* , O. Rimon, Reichmann. Defining Hsp33's redox-regulated chaperone activity and mapping conformational changes on Hsp33 using hydrogen-deuterium exchange mass spectrometry, J. Vis. Exp. (136), e57806. Link to the video 

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D. Reichmann*, W. Voth, U. Jakob*, Maintaining a healthy proteome during oxidative stress, 2018, Mol Cell, 69(2):203-213. *corresponding authors

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Rimon O. and Reichmann D. Kfits: A software framework for fitting and cleaning outliers in kinetic measurements. (2017). Bioinformatics, 2017, 34(1):129-130

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On the cover: Rimon O*, Suss O* ,  Goldenberg M,  Fassler R, Yogev O,  Amartely H, Propper G, Friedler A, and Reichmann D. A role of metastable regions and their connectivity in the inactivation of a redox-regulated chaperone and its inter-chaperone crosstalk, Antioxid Redox Signal, 2017, 27(15):1252-1267.

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Groitl B, Horowitz S, Makepeace KA, Petrotchenko EV, Borchers CH, Reichmann D, Bardwell JC, Jakob U

Protein unfolding as a switch from self-recognition to high-affinity client binding (2016) Nat Commun., 7:10357

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O. Suss and D. Reichmann.  Protein plasticity underlines activation and function of ATP-independent chaperones, (2015) Front Mol Biosci., 2: 43.

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D. Knoefler, LI. Leichert,  M. Thamsen, CM. Cremers, D. Reichmann, MJ. Gray, WY. Wholey and U. Jakob. About the Dangers, Costs and Benefits of Living an Aerobic Lifestyle (2014), Biochem Soc Trans, 42(4):917-21.

abstract: http://www.ncbi.nlm.nih.gov/pubmed/25109979

 

 

M. Abu-Odeh,  T. Bar-Mag, H. Huang, T. Kim, Z. Salah,  S. Abdeen, M. Sudol, D. Reichmann, S. Sidhu, P. Kim, R. Aqelian. Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks (2013), JBC, 28;289(13):8865-80

http://www.ncbi.nlm.nih.gov/pubmed/25109979

 

 

D. Reichmann and U. Jakob. The roles of conditional disorder in redox proteins (2013), Curr Opin Struct Biol, 23(3):436-42

http://www.ncbi.nlm.nih.gov/pubmed/23477949

 

 

N. Brandes, H. Tienson,  A. Lindemann, V. Vitvisky, D. Reichmann, R. Banerjee, U. Jakob. Time Line of Redox Events in Aging Postmitotic Cells (2013), eLife, (2),e00306.

http://www.ncbi.nlm.nih.gov/pubmed/23390587

 

 

D. Reichmann, Y. Xu, CM. Cremers, M. Ilbert, R. Mittelman, MC. Fitzgerald, U. Jakob, Order out of Disorder - Working Cycle of an Intrinsically Unfolded Chaperone (2012), Cell, 148(5):947-57

 The preview article was published in Cell, 148(5):843-4.

http://www.ncbi.nlm.nih.gov/pubmed/22385960

 

 

N. Brandes*, D. Reichmann*, H. Tienson, L. Leichert, U. Jakob. Using quantitative redox proteomics to dissect the yeast redoxome (2011), J Biol Chem, 286(48):41893-903

*authors contributed equally

http://www.ncbi.nlm.nih.gov/pubmed/21976664

 

 

 

U. Jakob and D. Reichmann. Oxidative Stress and Redox Regulation (2013) Springer, ISBN 978-94-007-5786-8